A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections

Teicoplanin is a glycopeptide antibiotic commonly used to treat Gram-positive bacterial infections in the clinic. The aim of this study was provide therapeutic reference for clinical application and dosage regimen adjustment teicoplanin by identifying factors associated with its plasma trough concentration (Ctrough). A retrospective performed on patients suspected or documented who were hospitalized from November 2017 January 2020 treated while undergoing routine drug monitoring (TDM). total 112 Ctrough measurements obtained 72 included study. SPSS software correlation analysis receiver operator characteristic curve (ROC) analysis. showed statistically significant relationships (P<0.05) PLT, Scr, CLcr, eGFR, BUN Cys-C. ROC revealed that CLcr eGFR more sensitive specific compared other factors. These findings should be considered adjustment.